That idea kinda falls flat if you think past what your character would do and instead think about what they would do.
Wyll will join you, but only if you promise to help him with Karlach. He's already more interested in hunting Karlach than getting rid of the tadpole anyway.
Karlach will gladly join you but if Wyll's there, they'll fight because there's no tadpole magic telling you she's not who Mizora says she is. You have no reason to spare her other than her word, and if you do, Wyll won't. If you meant that you're tadpoled but just don't know the threat, then tadpole magic could probably still happen and things transpire the same way they do now.
Astarion has no reason to join you. What use does he have for you if not to find a way to cure (or in his case, a way to control) the tadpole, if he doesn't know it's a threat? He's just happy he can walk in the sun again.
Gale might tag along assuming you're willing to help him with his personal problem.
Shadowheart may join you, since she's being hunted for the artifact and could use your protection.
Lae'zel will kill you on sight. Githyanki aren't exactly friendly. She's only reluctantly letting you be her 'servant' because she knows the depth of the tadpole issue.
And good luck ever getting Shadowheart and Lae'zel in the same party, considering what transpired before the tadpoling. They already don't want to be, and without your persuasion, will kill each other (as is in game, Shadowheart kills Lae'zel) regardless of the tadpole. Imagine how that'd go if their only concern was the artifact.
Last edited by Michieltjuhh; 08/10/23 10:18 PM.