I am having a similar bug but I am almost done Act 2.
Hovering the mouse over characters shows the dialogue icon, but clicking on them does nothing. I discovered the bug on a different save that I was trying out some mods so I thought it was those, but it still happens on my no mods save, even after deleting them. On the mod save I also cannot fast travel or travel to the camp at all.
I've seen 1 similar post about this on Reddit, and it seems to be related to the latest Hotfix update. Hopefully they can get it fixed soon.
