There can be a few "advantages" (lower DC of particular skill checks) and the ability to bypass the need for a check completely dependent on class, race, and in even gender. Most of extra comments are benign. A few might get nasty return comment, but no real "disadvantage" to game play. There are few "disadvantages" in Story and Balanced play. I am aware of one interaction that does not happen in Act 1 if you are Drow, but it is meant to be a roleplay opportunity. That changes in Tactician mode though. Some things just might require some forethought, or quick thinking if you are not familiar with the general racial views within Fearun. "F8"(on PC) is quick load to last save in the event you may feel the need.
