I've been focusing on Astarion, Karlach and Minthara the most in my walkthroughs. Well shit... that's where the "sad journal" really is. Well and Minsk and Jaheira, but they appear only in the third act, so they don't have much content, and even less if you play not as Dark Urge. But I'm also familiar with the quests of all the other Origin characters. And yeah I've got them all running through my head right now, and Karlach's quest looks like "Bring it, give it, go f*ck yourself".

The one character I'm not familiar with at all is Halsin, because of Minthara. I always kill him and only know that he can help in act 2 with restoring the land from the curse. (although why can't the Moon Maiden's Blade and Isobel do that?).