Obsidian management had always voiced the interest of using the IP for a more Skyrim-like project. The thinking on the business side seemed to be very quickly after POE1 was a success that: "Our very own successful IP + Skyrim = $$$$$$$$$$$$."
But who knows.

I am hoping now that BG3 was so successful it will change from lots of rpgs trying to be Skyrim to lots of rpgs trying to be BG3!

I think there could be a good game out of the serious, but I think that Obsidian really needs to revisit the combat system from the ground up if trr get Ray do a PoE3.
He said in the interview that he would like to design encounters around being turn-based if he did PoE3.

Another thing I would like them to take from BG3 if they did a AAA PoE3 is pacing of quests and main story. For me PoE2 had huge problems with pacing and too much emphasis on factions. BG3 lets you go where you want but still has great pacing and is story focused.