I'm surprised more people haven't written about it yet. Because I think it's a big mistake that the environment doesn't react to it at all.
Similar to Durge's
scene, none of the companions seem to care.
You don't feel integrated into the group/world if extreme changes aren't noticed.
I thought there was a mistake in my save, because I was really expecting comments and changes.
And I think that the player shouldn't be able to change red eyes or pale skin anymore, you should feel the consequences.
I hope for at least a few small recognitions. And of course the fangs.