I think it’s really obvious that you can remove Karlach from the party permanently by killing her. Not sure why this is still a question, saw your other post.
I tried to kill her, if she is dead Minthara still thinks you are into the dead. I can't remove her from the party permenantly without getting her to leave like attacking the druid graove. I even told her that I was the Sciaon of Bhaal and I kill the cleric in act II dooming everyone to the sahdows and she is still hanging around. I had her jump in a death pit and her body is still back at the camp and her soul with Withers. So if you know of a way to get her to leave the party permenantly in Act II, please let me know.
