I going on my second run with a spore druid urge.
I inserted on the top of my rules what was missing from Zentu's Dwarf rules. So like no death /no save scuming/ no tadpole / limited resting /no respecing /no multi classing /no elixir/ solo/ only use lockpick one try if it fails it fails.
All in all to add no elixirs aren't really an issue actually its just makes the game slower. Also lockpick makes the game slower.i mean I can still trow down the chest from a high roof.
Currently I had zero issues.

I think the biggest issue that makes this game easy are wendors. They are constantly refreshing they stock on resting and on lvl up that makes healing potions unlimited. Also I find them too cheap. After act 1 its not even essential to use the vendors that's mean that the difficulty curve are falling down dramatically.
At act 3 a defensive play style cannot be even hitted any more. And this happens all because of critical immunity. Another ridiculous problem.

All other things are just cherry on the cake because if I can do it there is at least 1 million people that can do it as well. Because I am not a good gamer for sure I am not the top 10 %.
I am just playing w/o looking for guides or broken items.