This happens to me as well, although with a slightly different "flavor".

I'm essentially stuck in Wyrm's Crossing, having just dealt with Ansur and Gortash, and every time I attempt to go back to Lower City the game loads to 100%, the loading screen dissapears and then a very brief white overlay appears (Think a white filter on the entire screen) that fades to reveal the main menu. Finally, an error message pops showing BOTH codes 222 and 223. Attempts to load a save directly after that will crash the entire game, I have to restart it to get back in.

I'm running on PC, no mods. Have tried going back a few saves (to before Gortash, for example) but the behavior persists.