No mutants Allowed intervewed J.E. Sawyer, where they tried to discuss Van Buren and Fallout 3 as different projects. And as a result - nothing new on Van Buren, but for Fallout 3, there are some new details from the point of view "If we would have been making it then ..."

- In character development the player will be able to choose between humans, ghouls and super-mutants
- Story line will not be connected to Vault Dweller / Chosen One
- That would be a sequel, i.e. after Fallout 2.

http://www.nma-fallout.com/forum/viewtopic.php?t=1133

After all this we can only guess what will and what will not be in new game.

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"Endure. In enduring, grow strong." -Githzerai adage.