Even for a fairly well-sighted person, some of the icons on screen are absurdly small and the click boxes to interact with them even smaller. (Example: trying to drop concentration on a spell.)
While I hope Larian will make changes, game studios need to normalize making accessibility a core feature by default. For such a well crafted game, it is a glaring omission.
When I was young I never thought my body would give me trouble doing basic things, but here I am. There are accessibility consultants than can help smooth the learning curve. Please use them.
OP: Do consoles not have magnifying glasses and screen readers built in? They may not work for your situation, but if you haven't tried them, perhaps they can. Of course, it still doesn't excuse accessibility features being missing from BG3.