Oo, for those of you who really liked Us
Did you guys add US as a familiar? My first two playthroughs I completely missed it, but in Act 2, I found Us in the Mindflayer colony! Us was still alive and you can save it from its cage. Although, it was green and purple and not the pink it was in the beginning. Looked like someone poisoned it

Yes! And Chop has dialog about him and why he is in the cage. We truly saved him. Well, not the brain donor but he was a lost cause anyway.