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JandK:

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Again I repeat, it doesn't make any story sense to get special powers or resistances for not using the tadpoles.

I mean, you can play it that way of course, everything is viable. I like roleplaying my characters and motivations and I'm used from our DnD rounds, that actions like that have consequences.

I see it from lore perspective: we play either someone living in Faerun or a Githyanki and it is likely (for sure in the case of the gith) that you know about the dangers of mindflayers. You just don't put more tadpoles into your brain willynilly - that just doesn't make sense. So not using them should at least make you keep your health - and as a consequence for using them, you could have those awesome powers, but it would make sense, that some stats are reduced - those tadpoles are tunneling through your brain after all.

"We are all stories in the end. Just make it a good one."

Doctor Who