It just occurred to me, Dragon Age isn't exactly averse to having characters otherwise fated to die avoid death either. Origins has the old god baby thing that lets the Hero of Ferelden and Alistair/Loghain get out of dying from killing the archdemon, Fiona got cured of the taint in the books and lives a relatively normal life, or at least as normal as a mage can get in that world, Avernus from Origins' Soldiers Peak DLC lived for over two centuries despite the taint having a 30-year limit because of blood magic and his experiments, the Inquisitor loses an arm to save them from the mark killing them in Trespasser and the HoF (assuming they lived past Origins) is off looking for a cure to the Calling.
It's not as open-ended of a setting as DND and not as bleak as Cyberpunk, so...
