the Inquisitor loses an arm to save them from the mark killing them in Trespasser
Oh yeah, I remember the "Your hand is killing you" thing was VERY convincing in Trespasser the way they build up the tension, I was fully expecting to watch my Inky die by the end there. And yet!
Good point, by the way, the Inquisitor and the Warden being the biggest examples.
(also lest we forget than even Shepard in the infamous three colored ending choice of "die, die or technically die" has a chance to survive under certain conditions.)