- Possibility to cure non-ascended Astarion of vampirism (for example in Avernus / via God Gale's intervention / using Gale's scroll of True Resurrection etc).
Pretty sure Jaheira knows something about cures for vampirism too. But if they let that happen they also have to give Karlach a working heart.
I'd settle for finding a way for him to go out in the sun once in a while.