Basically, there's a portion of the screen where my mouse isn't the iron Bg3 glove, but the desktop mouse symbol. That portion of the screen is directly where the fast travel options are. As such, I've had:
-- none of them work
-- half of them work
Sometimes it goes away, sometimes it doesn't. Really annoying. For some weird reason, while it's the desktop mouse symbol, they still light up, I just can't click them. It understands and doesn't understand the input at the same time