I recently finished Honour Mode, I had no crashes until late into Act 3. I was terrified my save would be corrupted. The first one happened in the House Of Grief. I had saved just before entering the room/starting the fight but I was not at all happy about having to do that long battle again. Same happened towards the end too. Game crashed on me while killing the final enemy in the big courtyard battle. I had to do that all over again too! Thankfully my save was fine. I have heard people say their saves were corrupted from crashes but thankfully I was able to reload.
The fight that nearly ended me on my HM run was Cazador. I wasn't expecting anything special from him as he's never posed a problem to me before and, yeah, well, that was a humbling experience.