My two cents - this is a slippery slope and Larian shouldn't create a new mode thats even more difficult. There will always emerge a meta game that breaks the mode (or the mode will be rng/impossible/unfun) and there will always be people coming out of the woodwork that claim that the mode is 'too easy' after metagaming it. What makes things worse is that save scumming is trivial, even in honor mode and people certainly are abusing it.
Instead, I think there should be more options in custom mode to make the game more difficult: i.e. toggles for allowing or removing legendary and very rare gear, increased supply requirements, prevention of scrolls being used other than scribing, customizable attack roll penalties, enemy hp buff %s, etc. That way the min maxers can knock themselves out with pushing the limits of the game without Larian wasting their time and resources catering to a miniscule portion of the playerbase.
The game as is is plenty challenging for most players who aren't actively trying to cheese or break it. I'd rather Larian invest their time and energy in fixing act 3 bugs and coming out with DLC or better yet another game than wasting their time on this.
