2 things that I probably would have save scummed in my current run if it wasn't for Honour mode:
1) Not due to a bad roll, but due to missing a dialogue option in a Shadowheart romance.
Asked Shadowheart to tell about herself, but didn't pick an option about "something besides Shar and tadpoles". I thought I'll be able to return to this conversation later, but the line to ask her about herself was gone from that point on and I didn't want to restart a run because of this. Now I can't gift her night orchids and her Act 3 romance scene won't trigger, because it is tied to this one conversation way back in Act 1. RIP sand castles.
For (1), there is a possible "second chance"/"alternative"
Give Shadowheart the Idol of Shar from act 1 Grymforge.
