It feels indeed like patch 4 broke a lot of possibilities. Patch 5 only gave it the rest so the ganme does no longer agree with many mods and you have to test which mods work till the epilogue.
Currently the worst thing for me is, that the bugs are so game breaking, the game doesen't even find my save games anymore. So what is left to do? I have to start again.
I miss the time of patch 3 when i was able to play till the end, with mods! Larian, please make the game agree with mods again.
