Astarion used to have some lines for ascendant and spawn mixed up, maybe it's the same for Gale.
Maybe. He's pretty utilitarian on the whole and is often ok with things that aid a greater good. (In this case defeating the Brain.) It's just odd that he disapproves of betraying Shadowheart with -5 and is overall wary of the Shadow Weave in the Cloister but his dialogue, while somber and disillusioned in tone, does not reflect that. Then again, maybe he also just doesn't feel like moralising and replies with melancholia instead because he knows that blowing himself up might also be the safest choice to end the matter in the end.