I too don't get the connection between events in the Shadowfell and the inn. If anything Selune's personal loss could well increase the resolve to aid her cleric.

Shar's triumph in having a new chosen, SH, is tempered by the shadowcurse being unleashed by and still in service to Kethric, her disavowed.

SH even comment that ending the shadowcurse would allow Shar to simply redirect her power somewhere more effective.

The linkage between events is tenuous at best. I get that this explanation suits best:
...Instead what happens is Selune's power concentration wavers because her own daughter just got murdered so Isobel can no longer channel enough power from her goddess and everyone dies.
But here, we the player are making sense of events - unless some narrator line is said during Aylin's death that we're omitting?