I do not play DnD, and at first the dice roll system might be a bit unfamiliar, but I think it's a good system for a cRPG (without the Karmic Dice). I got very accustomed to it over the years, at least in combat. Sometimes you have luck and sometimes not.
Where I don't like it is in some rare dialogue situations. Generally you can make the dice system bearable in dialogues by choosing appropiate numbers you have to reach. And usually I'm ok with fails, I did not reload even when I could and dead children were the result. But in some seldom situations I could not accept Larian's concept of imposing crab on me by using very high numbers. A problem in Honour mode. I had the only moments in gaming ever where I hated developers. Only a mod made it possible for me one time to play further because I absolutely did not want the (visual) result Larian wanted to force on me.
What I also don't like is that often in the game paths for progressing in quests are hidden behind perception checks. I can live with it, but it's unfair and bad design.