As I said in the otehr thread, mostly bugs get me - when I met Raphael for the first time at the harper camp near the Emerald Grove and he teleported me to the House of Hope, the game stuttered and crashed - instant panic attack. I fought the spider matriarch and convinced the owlbear to stay peaceful and that damn devil ruins my honour mode without me even saying anything against him (yet). But luckily crashes don't destroy honour mode, so I was able to just boot up in the beginning of the House of Hope again and all went normal.
I so far haven't lost anyone, but some more serious bugs - like the party skip turns bug in Moonrise or a bug, that prevents me from lifting the Shadowcurse. Halsin just vanished from my camp without comment (which is a good thing) and some other strange things. During the Marcus fight the game froze and I had to close and open again.
My biggest panic attack so far was the Yurgir fight, I wanted to go the lick teh spider and convince the displacer beast to leave route, accidently hit the wrong button, got out of stealth and started the fight with disadvantage with Yurgir and Co above me. I had luckily good initiative and threw every lingering AoE up there from Arms of Hadar to Spike Growth. It worked, I killed them with not much lost health on our side. Ketheric was a walk in the park compared to that scare.
My girl was mostly lucky with preventing fights, since she is a sword bard/archfey warlock and can basically sell bathing suites in Icewind Dale. She is in Rivington now. My biggest fear right now are House of Grief, House of Hope and maybe Orin fight (I'm not playing a Durge)
