I had this exact "issue" after I tried to see what a setting in the game's main menu would do. I clicked on the setting - well, then, the game ceased to respond to my mouse clicks from then on. That was the reason why I joined this official forum: because I couldn't reset that setting - because the reset would require a simple mouse click that had simply become impossible to do!
I hate a design like this. And I'm a software engineer.
