Seems hotfix 18 completely broke the script extender & mods due to something being wrong with the games exe file itself, i dont know the technical details but the game is no longer loading files properly.
More info at
https://github.com/Norbyte/bg3se/issues/293 and other similar posts there.
Please fix asap, not only is the game unplayable for many players but people can easily corrupt their save files without knowing anything is wrong until its too late (good bye honor save).
Only the modding community can do that, modders need to catch up and make their modding tools (like the Script extender), and mods, compatible with the latest game exe.
Thats the trouble with modding a game which has not finished being developed, you will always be wishing for everyone who makes the mods to catch up. And any game saves which have become dependant upon having the mod tools and mods working correctly will be borked in the meantime.
Larian cant do anything about mod tool and mod problems. Its not their problem.
And we certainly dont want Larian stopping patching the game for the sake of mod stability, that would be ridiculous.
You need to be asking the Script extender guys to fix asap .. But bare in mind that those guys are just unpaid hobby programmers, doing what they do in their own spare time, so you would be better off just being patient and not pestering them, or playing your game without mods and starting again, until the game is fully developed and modding the game becomes a stable practice sometime in the future.