I have had several play throughs, and finally beat the game in Honormode.
Have I seen everything? Not really, the one thing thats really left for me is the Minthara storyline but she is so buggy and broken that I am going to hold off for now.
I have had plenty of fun but I have one last playthrough in me. I love that Larian is continuing to support this game with updates, the last act while large it is kind of a mess. I am sure in a year or two with all the gradual updates, the definitive edition and dare I hope a DLC? I would definitely be coming back.