I think there is something very strange going on with the dice sometimes. This is sort of unrelated, but in one instance I was savescumming the persuasion check with Lae'zel in the Zaith'isk, I naturally failed the check multiple times, but the weird bit is my 3-4 inspiration rerolls were the same result every single time. I eventually passed the check - it's not impossible, but highly improbable I was rolling the same number every single reroll.

I always play with karmic dice off.