I tried playing Origin Karlach and romancing Astarion but.. there were a lot of inconcistencies with her touch that threw me off in act 1. Then in act 2, his confession still made it seem like he was banging her, which was not possible in act 1. After that I was just not immersed in the romance anymore. Oh dear, now we're going to get a unique confession for Karlach.
I think Astarion/Karlach would be the one romance I'd be fine with being impossible due to their very different natures and how much the tenderness and closeness from sex is pivotal in Astarion realizing he might want a more serious relationship from the player. It was extremely awkward when, during the forest scene, Astarion asked Karlach what to do because he can't touch her. I can't imagine him putting himself in that vulnerable position. He is confident when it comes to sex because that's what he knows really well, and I find it hard to believe he would make himself vulnerable putting himself in a situation where he doesn't know what to do. It was just jarring seeing Astarion's personality shift so much to accommodate Karlach's romance.