I've avoided such genres as vampire games in RPGs because I find the mechanics of guns difficult to accept. It's not the guns per se; I have no problem at all with firearms. It's that I cannot suspend my disbelief with respect to how much damage a single gunshot would do to a person. Yes, the same can be said for fantasy weapons such as a huge club wielded by a giant. But I don't know. Somehow, I can handle suspending my disbelief with fantasy weapons, but not firearms (or energy weapons in sci-fi games).
I don't have a problem with that tbh. And VtMB is such a good game. And they've put into consideration, how much damage you can do to a more powerful being. There is even one being, you can't really hurt much as a new born vampire xxx you have to avoid that being.