After a bit more playtime, I've settled on it being an issue with data not being cleared between reloads. Played the same non-durge character for a couple hours with a clean load and had no durge responses at all. Good to know, but it would have been interesting if your actions actually affected things like that.

In moonrise towers, did you have a masculine sounding guardian response line after finding the tentacle hole and sticking your hand in it? I had the same thing, threw me off because it should have been the feminine one.