Larian has a tendency to not make direct continuations of their games. Sure DOS1 and DOS2 are related but only in name. They changed a lot of the world and lore from what was established before, and not just small stuff but foundationally lore, and DOS2 contained little to no references to DOS1. When Larian starts a new game they tend to ignore what was done before. Same with BG3. It not really a sequel to BG1 or 2 but its own thing. The only thing each game carries on is the gameplay. So, I feel if they made a BG4 they would do the same that they did with DOS1. Time skip a hundred years and use new characters and new plots. The only reason people didn't complain about that in DOS2 is because DOS1 was very niche.