As for Nere I know for a fact that the game has multiple time sensitive stuff but it is connected to difficulty levels. Only when I started the honor playthrough I discovered that a lot can be missed. For example, my Florrick burned to death because I didn't went to the burning tavern right away after I found it. There is a guide on steam where most of these listed, I was surprised how many things were actually time sensitive starting act 1
Once you reach invisible and unnoticeable trigger ... yes.
That was my point.
Whole world is waiting for you ...
Floric can be blocked in her room for quite litterally years, if you Long Rest often enough ... and still perfectly fine ...
You can find the burning Inn and instead of helping her went to completely other way ... explore swamp, save Marina, save Zhentarims from Gnolls, kill/save Karlach, wipe out Goblin willage and their camp, and lots and lots of other stuff ... unless they changed something, but last time i tryed it was still possible ...
This "teaches" you basicaly, that there is no hurry. (Same story is with false urgency about your tadpole.)
Until you reach point where out of sudden, with no warning, time matters for a while.

That was my criticism ... incosistency.
Game teach you one thing ... and then sudently it makes exact oposite ... and i just feel like sometimes its for no other reason, than our not-so-friendly DM can have his "HA! Got ya!" moment ... and that sucks. :-/