Normally you are always hostile to the goblins once 2 of the 3 bosses are dead. There is also a debuff "Enemy of the Guard" or something similar, which you get if you kill a guard and there were witnesses and they survived. With this debuff you will also be attacked immediately. Sometimes there is a bug that the debuff doesn't disappear.
"Now, was that civilized? No, clearly not. Fun, but in no sense civilized" ~ Braingremlin
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