Character creation yes, other things no. The spear of night and Isobel/Aylin not appearing in camp shouldn't make it impossible to progress to Act 3, though?
I myself have had struggles with Act 2 NPCs disappearing -- lots of people did, actually. I also killed Shadowheart early because most often she was bugged in a patch. This is a major inconvenience, but not much more.
The shar version of the spear can give you a massive AoE nuke in the hands of a paladin, but otherwise, this weapon isn't that good. My guess for character creation is that you do not have modfixer, and/or tried to deinstall a mod improperly. Not all are easy to remove without damaging game files.
