I also find it strange that no one takes a clue from the steel watcher's comments on Karlach's heart. If the Gondians can make a stable version with better material and advanced technology, then the ironhand gnomes should also be able to do that also. The logical ending for Karlach, IMO, would be then to let her take refuge in the House of Hope, while we get either the Gondians or Wulbren to create a new heart for her that is stable in the material plane.
I also thought at some point that having Karlach stay at the HoH as a bouncer until her heart gets fixed would be a cute inbetween ending for her - until someone pointed out that she gets hunted by Zariel. So her staying at the HoH would endanger everyone living there. But it would be nice to at least have an option to talk to the Gondians about her heart - well, high hopes for patch 7.