Respec the origin characters into something similar, yet playing a different role in the party. Or just don't bring them for that run. Can't really go wrong with two fighters or two barbarians, either. If you feel like you need a cleric and a melee at the same time, do an ancients paladin. Or a storm cleric. Storm cleric with two levels in wizard isn't as strong, but incredibly versatile.
I've done my last run without a dex character. The sorcerer ended up designated lockpicker. Knock goes a long way for what she couldn't do, but traps will just have to occasionally blow up in your face. Use the weak health potions that are not really useful in combat after Level 5 anyway. Somewhat uncomfortable to play that way, but it's not a *struggle*. There's an item with unlimited cat's grace that let me get away with a lot when needed.
