I hold my original first playthrough as Bard (College of Swords) and Rogue (Thief) and my first successful honor mode run as Sorcerer (Wild Magic) and Rogue (Thief) as the two I enjoyed the most.
My first playthrough was a wild magic sorceror with a few levels of rogue. I loved wild magic, but I'm not sure I'm brave enough to try it on an honour mode run so respect! In my playthrough there were really fortunate rolls (I recall the fight against Raphael was made much easier when half the enemies were suddenly turned into cats and dogs) but I also seem to recall narrowly escaping a few times when magic went awry. Generally, though, sneaky witch-thief characters are my default, and tend to be the first class I play in any cRPG when available.
But my second run as jack-of-all-trades surprised me with how fun it was. I'm really glad I tried that.
Those are the only two runs I've finished. I'm slowly slogging through my first Durge run as a gloomstalker ranger and am just exploring Rosymorn Monastery, but don't feel I've quite worked out how to use him properly yet. And I've just defeated the goblin leaders in my second attempt at my open hand monk honour mode run. He doesn't feel as though he's come into his own yet, either, but I have just picked up the tavern brawler feat and am hoping that'll make him more effective and fun to play.