@SteelTempest: Not to forget Halsin and his cryptic "I am sorry, but Mystra is wrong about you, Gale." What? Why? What do you know that I don't? It's the one that confuses me most of all. All the others can still be seen as a reflection of their past break-up and as concern that the reunion might not go well, but Halsin seems to be very certain about Mystra's opinion of Gale.
I don't feel Wyll is especially tied to the main plot - only Gale, Lae'zel and Durge are baked into it, Shadowheart maybe - but it's weird that you can't even suss out what his opinion might be and maybe have to convince him away from it. Depending on what you pick, he sometimes seems to fluctuate between defender of the Sword Coast and power-grabby noble within seconds without any foreshadowing that political power might be an interest of his. I also don't think it was the best decision to have his plot get even more muddled if you recruit Karlach than if you let her die in act 1.