I stand by my point. That final 25 constitution check is unfair/incoherent.
The GOOD playthrough :
You are a goody-two-shoes, you may enjoy the best illithid powers the game can offer. Heck, you can have a partial illithid brain full of tadpoles and the game will never punish you for it...
Far from it, the tadpoles just magically disappear at the end of the game - even if you are partial illithid - no questions asked. You won, go home, enjoy the wine.
The EVIL playthrough :
You play an evil character, somehow, the price of using tadpoles or becoming partial illithid now weights heavily on your shoulders. You rightly think your total control over the Netherbrain/Netherstones protects you...
Nope my friend, you are suddenly punished, must roll a 25 constitution check or go full illithid/full Grand Design, you tadpole-using (evil) roleplayer. Sorry, no choices for you.
The BOTTOM LINE : That constitution check doesn't make any sense and steals away the fun of having a victorious evil playthrough in BG3.