My first ever game completion was the 2nd Honour Mode run.
First Honour Mode attempt (which was also my first ever playthrough of ACT III since I was saving myself for it up to that point) ended at the very finale as I went in completely blind and failed to foresee Lae'zel possibly betraying me during the endgame. Was roleplaying an evil Dark Urge who intentionally deceived everyone into becoming Chosen zealots of their own deities, so that when I dominate them I'd have powerful individuals to doom the world with. But Lae'zel's massive persuasion check at the finale was unexpected so by losing her I lost the run due to lack of damage during the final fight 
Immediately started the 2nd run with the exact same choices as before, but this time came prepared for her persuasion check and succeeded in world domination as was originally intended

Now I just play Custom Honour Mode without the single save restriction because I really love its unique challenges, but have to be able to save for bug reporting purposes.