+1 on making it your playthrough. I went in without knowing what's behind the next corner or how any of the interactions or companion quests would play out and I love the story that grew out of it with all scars and pimples. F5/Quicksave makes you an awesome chronomancer who can see variantions of the immediate future. Sometimes, I would just explore all the silly/stupid/good/evil dialogue options, have a laugh and then proceed with the one I would have picked in the first place. Enjoy your journey!