Supposedly, the inspiration is attainable in all 3 acts.

I personally only know of the trigger from Zorru in the Grove.

Though, I can think of a few examples where it might be possible to obtain it during act 2 (Spoilers);

- When heading towards the Temple of Shar with Astarion in the party. He will want to ask Raphael about his scars. You can make comments against that.
- In the Temple of Shar, Shadowheart will ask to be the one to pay the offerings for the trials. You can deny that request.
- Heading towards Moonrise Towers and encountering Mizora will prompt Wyll to make comments. You can dismiss his concerns.
- Meeting with Mol at Last Light will cause Karlach to express concerns about her. You can be dismissive of her concerns.

Again, I'm not sure if any of those will trigger the inspiration. But they're worth a shot. The general idea behind the inspiration is to try and dismiss concerns raised by a companion during a dialogue.