Are you the sort of person that can play a game for multiple play throughs? If you are, go for something you are familiar with, [melee is laezel, blasting is gale, sneaking is astarion and blasty, bashy supporty is Shadowheart]
Play through, have a ball, after a few levels, restart with something you want to do.
Save frequently.
Once you have Withers, you can rebuild all characters, so you can change things about, at the drop of a hat.
Character personality is important, I leave Gale & Wyll in camp, as I think they are dicks
Dogmeat is called Scratch!
Enjoy yourself and please come back for tips or questions, we are always happy to give a wide variety of replies