Lol, let me see:
1. Vases are generally empty. Very sad.

2. Efficient healing requires snuggling (sorry Astarion). Make your buddies stand together and throw a potion at their feet, it helps all of them.
3. Let yourself get arrested. BG3 prison break experience is 10/10.
4. Sometimes not being the nicest gives you the better scene. I am a sucker for conflict resolution, so I am very happy BG3 gives you the opportunity on several occasions. Peering into Gale's mind twice and then immediately being remorseful about it, might be my favourite example, but I also dearly love the conversation you can have with neutral approval Shadowheart at the Tiefling party.
Edit: When playing Avatar-Gale for the first time, I also collected all the books, notes and letters. Karlach and Lae'zel carried them around, best girls. ^^ (It made Karlach's epilogue comment all the more funny.)