What are quests, you really look forward to? Or areas?
I love the whole Shadowcursed Lands scenario, it is very lovecraftian and I'm a huge horror fan.
I also really like - and I know that is an unpoluar opinion - the Iron Throne. I really like coming up with new ways, to get everyone out in time and so far, I always managed it somehow, despite some pretty stupid things I did.
In act 1 I love the swamp area and Auntie Ethels place - very creepy and I love Auntie, she is such a fun villain.
In act 3 I actually like the murder chase, starting with the Ilmater temple. And Wyrms way. Ansurs story is pretty sad.