I think all tadpoled companions should be able to step in here.
Lae'zels case was already discussed. She wants Orpheus to free her people? Then she can turn to a mindflayer herself . No way, I'll do that. While I sympathise with her situation, the githyanki people are not really my problem, I already solved enough.
But I think everyone of the companions could be motivated to do it. And being the most romanced I wouldn't take as an argument, since ultimately it comes down to player decision. But I never understood why my characters should sacrifice themselves to become a mindflayer. So in my case Orpheus will always be the one, who has to change.
