Wow, some very good ideas have been presented here. Here's my perspective and as always thinking a bit far into the future in the unlikely event of a sequel:
Gale as a nuclear bomb seems to me to be the best solution so far. Mystra will revive him somehow. She has some practice at it herself.
Jenevelle (Is she actually called by her real name again if she chooses Selûne instead of Shar?) Well, anyway, I could well imagine in a sequel that a twin sister suddenly appears and of course Jenevelle will represent Selûne and Shadowheart Shar and continue the battle of the twin goddesses as mortals, so to speak.
Ascended Astarion I would have liked to have seen as another solution, and pretty much the reverse: i.e. not twisted, insane and dumbed down version of a
Vampiric Illithid or vice versa.
