I am mod clean (never had mods downloaded in the first place) and noticed this issue as well, first I thought maybe its my save file because its from a playthrough when patch 5 was released.
Anyway I have a save file just moments before I talk to Karlach for that Act 2 romance scene she has that bubble over her head, it has worked like a charm through every iteration of the game up until patch 8, now its like never triggered and all broken.
I talk to Karlach she still has the bubble over her head, she wants to see me so I go to bed and it never gets triggered, I just sleep through the night like any other normal night.
Hearing this issue from players doing a new game from scratch worries me now, I really hope it gets looekd into they probably should be receiving a handful of reports.